Abstract: Objective To investigate the prevention and management of the hemorrhage during laparoscopic cholecystectomy( LC), and improve success ratio. Methods The medical data of 420 cases with LC from May 2003 to 2009, September were analyzed retrospectively, including total number, hemorrhage site and ways of prevention and management. Results 417 cases experienced successful C,with success ratio 99.3%. 49 cases ( 11.7% ) had hemorrhage, and in 46 cases(93. 9% ), it was stopped by laparoscope or hemostasis by compression,3 cases were rescued by operation. All hemorrhage sites included 15 cases(30. 6% ) in triangle de Calot,26 cases(53. 1% ) in gallbladder bed, and 8 cases ( 16.3% ) in incision. Conclusion A reliable opetration and appropriate hemostasis are critical of the successful operation and prevention of complications after LC.