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Effect and mechanism of arsenic trioxide on LRP mRNA expression in human lung adenocarcinoma cells in vitro

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
Issue:
1
DOI:
10.3760/cma.j.issn.1008-6706.2010.01.003
Key Word:
三氧化二砷;肺肿瘤;基因;细胞凋亡;Arsenic trioxide;Lung neoptasms;Genes;Apoptosis

Abstract: Objective To study the mechanism of arsenic on human lung adenocarcinoma cells.Methods MTT,FCM and RT-PCR tests were used to investigate apoptosis levels induced by arsenic trioxide and the effect on LRP mRNA expression.Results 1.0μmol/L and 3.0μmol/L arsenic trioxide can decrease LRP mRNA expression.Conclusion Low concentration As_2O_3 may improve apoptosis of lung caner by decreasing LRP mRNA expression.As_2O_3 may be used to treat lung cancer but the results are not better than cisplatin.

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