Abstract： Objective To investigate the value of multi-slice CT in the diagnosis of gastrointestinal stromal tumor. Method CT image of 15 cases of GIST confirmed by surgical pathology were analyzed retrospectively. Re-sults The tumors originated from the stomach(n = 8), duodenum (n = 1),jejunum and ileum (n = 3), colon(n = 1), mesentery(n = 2). The main display of CT were hemorrhage,necresis and cystic change within the tumor. The en-hancement of parenchyma was clear. The enhancement of venous phase was more clear than that of arterial phase. Conclusion MSCT is a valuable examination for GIST. MSCT can precisely display the location, shape, size and en-hancement of GIST. MSCT can be worth the locating,qualitative and staging diagnosis.