Evaluating prognostic value of plasma Nt-proBNP in patients with congestive heart failure

( views:204, downloads:0 )
Author:
PAN Hao-quan(Department of Emergency,The First People's Hospital of Foshan,Foshan,Guangdong 528000,China)
LI Kuang-yi(Department of Emergency,The First People's Hospital of Foshan,Foshan,Guangdong 528000,China)
LIANG Xi(Department of Emergency,The First People's Hospital of Foshan,Foshan,Guangdong 528000,China)
SONG Hong-mei(Department of Emergency,The First People's Hospital of Foshan,Foshan,Guangdong 528000,China)
LUO Jing(Department of Emergency,The First People's Hospital of Foshan,Foshan,Guangdong 528000,China)
Journal Title:
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
Issue:
Volume 15, Issue 08, 2008
DOI:
Key Word:
Heart failure;congestive;Natduretie peptide;brain;Prognosis

Abstract: Objective To determine the evaluating prognostic value of plasma Nt-proBNP in patients with congestive heart failure.Methods 107 patients with congestive heart failure were included in this study,followed the degree of rehospitalization and mortality rate of the cured patients after left hospital.The plasma concentrations of Nt-proBNP were measured by enzymelinked immunozorbent assay(ELISA).Results Concentrations of Nt-proB-NP of Ⅱ,Ⅲ,Ⅳ classincation were(1129.8±383.2),(5849.7±567.6),(9506.3±492.4)ng/L in NYHA functional classification respectively(P<0.01);the plasma level of Nt-proBNP had significant positive correlation with NYHA functional classification(r=0.759,P<0.01).The degree of rehospitalization were(0.85±0.96),(1.98±0.86),(2.58±0.91)respectively(P<0.01);mortality rate were 8.3%,12.5%,45.2%respectively(P<0.01).Conclusion Plasma Nt-proBNP level may be the more important clinic value in evaluating prognosis in patients with congestive heart failure.

  • [1]赵丽,吴学思,韩智红,等.B型钠利尿肽检测对心力衰竭患者的临床评估.中华心血管病杂志,2004,32(1):51-52.
  • [2]Clerieo A,Del RS,Giannessi D.Measurement of cardiac natduretic hormones(ANP,BNP,and related peptides)in clinical practice:the need for a new generation of immunoassay methods.Clin Chem,2000,46(10):1529-1534.
  • [3]Pemberton CJ,Yandle TG,Rademaker MT,et al.Amino-terminal proBNP in ovlne plasma:evidence forenhanced secretion in response to cardiac overload.Am J Physio,1998,275(4 Pt 2):H1200-1208.
  • [4]汪芳,李卫,黄洁,等.血浆N-末端原脑利钠肽水平对慢性心力衰竭患者长期预后的预测价值.中华心血管病杂志,2006,34(1):28-32.
  • [5]Chiu KM,Chan HL,Chu SH,et al.Carvedilol can restore themoltifractal properties of heart beat dynamics in patientswith advanced congestive heart failure.Auton Neurosci,2007,132(1-2):76-80.
  • [6]Tsutamoto T,wada A,Maeda K,et al.Plasma brain natriuretic peptide level as abiochemical marker of morbidity and mortality in patients with asymptomatic or minimally symptomatic left ventricular dysfunction.Eur Hear J,1999,20(24):1799-1807.
  • [7]Mc Donagh T,Cunningham AD,Morrison CE,et al.Lefventricular dysfunction,rmtriuretie peptide,and mortality in anurban population.Heart,2001,86:21-26.
  • [8]李永健,王林,陈元禄,等.N-末端脑钠素原对冠心病心力衰竭诊断及预后判断的价值.天津医药,2004,32(6):333-335.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn