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Effect of thalidomide on the expression of VEGF mRNA in human breast cancer cell lines
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-6706.2008.07.001
- Key Word:
- 乳腺肿瘤;沙立度胺;血管内皮生长因子;细胞系;Breast neoplasm;Thalidomide;Vascular endothelial growth factor;Cell lines
Abstract： Objective To assess the effects of thalidomide on VEGF mRNA level in human breast cancer cell lines. Methods Breast cancer cells were treated with thalidomide for 24～72h, RT-PCR was uced to detect the level of VEGF mRNA expression. Results When the concentration of drug is 50μg/L,thalidomide strongly inhibited the level of VEGF mRNA expression. Conclusion Within certain concentration range of thalidomide can inhibit the level of VEGF mRNA expression in breast cancer cell.
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