Abstract： Objective To approach therapeutic effect of captopril combined with amiodarone in treating acute myocardial infarction complicating atrial fibrillatio. Methods Select acute myocardial infarction complicating atrial fibrillatio 62 patients, divide into two groups, therapy bundle offer captopril combine amiodarone, control bundle offer propafenone, compare rate of atrial fibrillatio turn over with 24 houres, control rate of atrial fibrillatio attack (reduce atrial fibrillatio attacking over 60%), tetain sinus rhythn, backward heart failure incidence rate, repeated infarct rate, hospitalization death rate, death rate one year later, stroke incidence rate within one year. Results Captopril combined with amiodarone in treating acute myocardial infarction complicating atrial fibrillatio, it can turn over atrial fibrillatio utility, control atrial fibrillatio attack (reduce atrial fibrillatio attacking over 60%), reduce repeated infarct rate (6.3% vs 16.7%), death rate (9.4% vs 16.7%), backward heart failure incidence rate (9.4% vs 30.0%), stroke incidence rate (3.1% vs 13.3%)(all P<0.01). Conclusions The therapeutic effect is certain about captopril combine amiodarone in treating acute myocardial infarction complicating atrial fibrillatio. And this method is safety. The patient profit from it in many ways. It deserves generalization and application.