Abstract： Objective The objective of this study was to explore the relations of quantitatively measurment of serum alphafetoprotein(AFP)and prognosis in severe viral hepatitis.Methods To retrospectively analyse the different level of quantitatively measurment of serum alphafetoprotein(AFP) and distribution of AFP in 213 patients with severe viral hepatitis.Results The abnormity rate of AFP was 68.1%,the abnormity rate of AFP in acute severe hepatitis patients was significantly less than that in subacute severe hepatitis and chronic severe hepatitis(P＜0.01),the death rate of patients with AFP＜20 μg/L,AFP 20～400 μg/Land AFP＞400 μg/L was 86.8%,58.8% and 20.9% respectively,the survival severe hepatitis parients were 85 cases with AFP(248.0±72.5)μg/L in 213 cases,128 cases with AFP(97.6±50.4)μg/L died(P＜0.01).Conclusion The mortality of severe decreases and the survival rates of severe increases gradually along with the higher level of AFP,and it reveals the higher level of AFP in severe hepatitis has a better prognosis,it is the important reference index of prognostic judgement.