Clinical assay of renin-angiotensin-aldosterone system,endothelin and nitric oxide in renovacular hypentension and adrenocorticoadenoma

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Author:
MA Lun(Department of Nuclear Medicine,Shenzhen Shekou Hospital,Shenzhen,Guangdong 515031,China)
WU Zhao-zhi()
Journal Title:
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
Issue:
Volume 15, Issue 02, 2008
DOI:
Key Word:
Hyperension;Rennin-angiotensm system;Nitricoxide

Abstract: Objective To investigate the roles of renin-angiotens in system(RAS)and aldosterone(ALD),endothelin(ET),nitricoxide(NO)in patients with renal hypertension(40 cases)and adrenocorticoadenomas(35 cases),35 normal subjects were included in the study as controls.Methods Radioimmunoassay(RIA)was used to de termine the plasma concentrations of the renin,angiorensin Ⅱ(AⅡ),aldosterone,ET in the abovecases.Enzymicas say was adopted to examine the plasma concentration of the nitricoxidesynthase(NOS).Results TIhe plasma concentrations of renin,angiotennsin Ⅱ,aldosterone,endothefin in the patients with renal hypertension were significantly higher than those in the control group(P<0.01)except with the concentration of NOS,which were lower than that in controls(P<0.05);the plasma concentrations of the ALD,ET,in the patients with adrenocorti-caladenoma were higher that those in controls(P<0.01)but renin and A Ⅱ were lower(P<0.05).Conclusion Determination of the plasma renin,angiotensionⅡ,aldosterone and NO might be able diagnose renal hypertension and adrenocorti coadenoma earlier.

  • [1]Dai H,Kaoru N,Takahiro O,et al.Preformance of the basal aldosterone to rennin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone produeing adenoma in low rennin hypertensives.J CEM,2001,86(9):4292.
  • [2]倪廷枢,何国祥.内皮素及其在心血管中的作用.心血管病学,1997,18(6):347.
  • [3]王向宇,吴可贵,许昌声,等.血管紧张素、内皮素对SHR主动脉平滑肌细胞的增殖的作用.高血压杂志,2000,8(2):176.
  • [4]张炜,汤正义,胡仁明.肾上腺静脉插管取血在原发性醛固酮分型增多症中的诊断意义.中国实用内科杂志,2004,24(3):152.
  • [5]张炜,汤正义,胡仁明.不同检查方法将特发性醛固酮增多症的诊断价值(附62例报道).实用临床医学,2004,5(5):72.
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