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Comparative effects of valsartan and extended realse nlfedipine tablets on lowering blood pressure and reversing left ventricular hypertrophy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-6706.2007.11.003
- Key Word:
- 缬沙坦;硝苯地平;高血压;肥大,左心室
Abstract： 目的 比较缬沙坦与硝苯地平控释片治疗原发性高血压(EH)逆转左心室肥厚(LVH)的作用.方法 选择100例EH伴LVH患者,随机分为缬沙坦组(A组)及硝苯地平控释片(B组)各50例.全组患者未接受降压治疗(或仅用过利尿剂)或已停用降压药物2周以上.A组服用缬沙坦80～160 mg,1次/d;B组服用硝苯地平控释片30～60 mg,1次/d.全组疗程24周.观察治疗前后血压及超声心动图变化.结果 两组患者治疗后血压均显著降低(P＜0.01),组间降压幅度差异无统计学意义(P＞0.05).两组患者治疗后舒张期左室后壁厚度(LVPWT)、舒张期室间隔厚度(IVST)及左室重量指数(LVMI)均有显著改善(P＜0.01).而且A组LVMI下降优于B组(P＜0.05).结论 缬沙坦与硝苯地平控释片在有效降压的同时均可逆转LVH,但缬沙坦对LVH的逆转作用优于硝苯地平控释片.
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