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The study of matrix metalloproteinase-9 and tumor necrosis factor-α in predicting chorioamnhionitis in patients with premature rupture of membranes
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1008-6706.2007.10.005
- Key Word:
- 基质金属蛋白酶-9;肿瘤坏死因子α;胎膜早破;绒毛膜羊膜炎
Abstract： 目的 研究胎膜早破孕妇血清中基质金属蛋白酶-9(MMP-9)和血清及羊水中肿瘤坏死因子-α(TNF-α)与绒毛膜羊膜炎的关系.方法 选取胎膜早破患者67例为研究组,并选择同期正常的40例孕妇为对照组,采用酶联免疫吸附法和放射免疫法检测血清MMP-9、血清及羊水中的TNF-α水平,产后对胎膜行病理检查.结果 (1)研究组羊水中TNF-α和血清中MMP-9水平明显高于对照组(P＜0.05),血清中的TNF-α无明显差异(P＞0.05);(2)研究组中破膜时间＜24 h组血清中MMP-9水平显著低于≥24 h组(P＜0.05),羊水中TNF-α差异却无统计学意义(P＞0.05);(3)血清中MMP-9水平在重度和轻中度绒毛膜羊膜炎组差异显著(P＜0.05),羊水中TNF-α差异无统计学意义(P＞0.05).结论 测定胎膜早破孕妇血清中MMP-9和羊水中TNF-α水平可判定是否存在绒毛羊膜炎,其血清MMP-9水平的高低,还可以判定破膜时间长短和绒毛羊膜炎严重程度.
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