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The study of radiosensitization of rhEPO combined with carbogen plus low concentration oxygen in middle-advanced medullary esophageal cancer

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
Issue:
9
DOI:
10.3760/cma.j.issn.1008-6706.2007.09.003
Key Word:
食管肿瘤;放射治疗;重组人红细胞生成素;氧;辅射增敏药

Abstract: 目的 探讨重组人红细胞生成素(rhEPO)结合高低氧对中晚期髓质型食管癌放射治疗(放疗)的增敏作用及不良反应.方法 将62例欲接受放疗的中晚期髓质型食管癌患者随机分为试验组和对照组.试验组:在放疗前1周给予rhEPO 30 000 U,皮下注射,每周1次,至放疗结束.放疗用6 MV X射线进行外照射,DT 1.8~2.0 Gv/次,每周5次,前后两野对穿照射DT 38~40 Gy后,再两斜野对穿照射DT 20~30Gy,中位剂量为DT 64 Gy.放疗过程中吸入高低氧.对照组单纯放疗,其射野和剂量同试验组,中位剂量为DT 66 Gy.结果 放疗DT 20 Gy时,试验组完全消退率(CR)为10%,对照组CR为6.5%(P>0.05);放疗DT 40 Gv时,试验组CR为33.3%,对照组CR为16.1%(P>0.05);放疗结束时,试验组CR为53.3%,对照组CR为25.8%(P<0.05);放疗结束1个月后,试验组CR为66.7%,对照组CR为35.5%(P<0.05).放疗结束时,Hb升高值试验组为17 g/L,对照组为-3 g/L(P<0.05);放疗结束1个月后,Hb升高值为试验组14 g/L,对照组为2 g/L(P<0.05).两组的血液学毒性发生率分别为33.3%和61.3%,差异有统计学意义.结论 rhEPO结合高低氧对中晚期髓质型食管癌有明显的放射增敏作用,血液学毒性较对照组轻微,并可预见能延长患者的远期生存,值得临床上进一步试用推广.rhEPO停用后1个月内仍有改善患者贫血的作用.

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