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Efficacy and safely of domestic produced amlodipine in the treatment of chronic renal insufficiency with hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-6706.2007.05.003
- Key Word:
- 氨氯地平;高血压;肾功能衰竭,慢性
Abstract： 目的 评价国产苯磺酸氨氯地平(兰迪)治疗慢性肾功能不全高血压的降压疗效和安全性.方法 慢性肾功能不全高血压病患者60例,给予苯磺酸氨氯地平5 mg/d治疗4周.治疗4周末坐位DBP＜80mm Hg,且SBP≤130 mm Hg者继续原剂量治疗至8周末;坐位DBP＞90 mm Hg或SBP＞140 mmm Hg者剂量分别加倍至10mg每日1次治疗至8周末.分别观察患者服药前后血压、心率和肝肾功能等生化指标变化及其不良反应.结果 60例患者均完成8周的临床试验.与试验前比较,用药第4周起,患者的收缩压和舒张压均有显著性下降(P＜0.01),降压总有效率达83.3%.不良反应轻而少.结论 国产苯磺酸氨氯地平治疗慢性肾功能不全合并轻中度肾性高血压有效,且安全.
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