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Nuclear factor-kappa B expression in rats following intracerebral hemorrhage and effect of astragalus polysaccharide on it
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-6706.2006.11.003
- Key Word:
- 黄芪多糖;核因子-κB;脑出血
Abstract： 目的 研究黄芪多糖(astragalus polysaccharide,APS)对大鼠脑出血(ICH)后血肿周围核因子-κB(nuclear factor-kappa B)蛋白表达的影响,探讨黄芪多糖抗炎的脑保护机制.方法 用Ⅶ型胶原酶注射到大鼠右侧苍白球诱导脑出血模型,并用APS干预.用免疫组化方法检测血肿周围组织NF-κB表达的动态变化,透射电镜观察术后3 d血肿周围神经元超微结构的变化及神经行为学评分.结果 与模型组比较,治疗组干预后3 d和5 d大鼠神经行为学评分明显减少(P＜0.05),6 h、1d、3 d、5 d时NF-κB阳性细胞数明显减少(6 h、1d P＜0.05,3、5 d P＜0.01).神经元超微结构改变亦比模型组减轻.结论 黄芪多糖可抑制NF-κB激活,减轻炎症反应,改善神经功能缺损症状.
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