You Position: Home > Paper
Comparative study of therapeutic effects of DF and GEM alone regimens of concomitant radiochemotherapy for stage Ⅲ～Ⅳa nasopharyngeal carcinoma
( views:268, downloads:8 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1008-6706.2006.06.002
- Key Word:
- 鼻咽肿瘤;放射疗法;抗肿瘤联合化疗方案;吉西他滨;顺铂;氟尿嘧啶
Abstract： 目的评价顺铂+氟尿嘧啶(DF)和吉西他滨(GEM)两组同期放化疗方案治疗Ⅲ～Ⅳa期鼻咽癌的疗效和不良反应.方法病理确诊的Ⅲ～Ⅳa期鼻咽癌患者187例分为两组,DF组94例,GEM组93例.DF组化疗于放疗第1、5周给予DDP 25 mg/m2,d1～5;5-FU 500 mg/m2,d1～5,均静脉滴入.GEM组化疗在放疗1～6周中同步进行,每周1次,每次GEM 200 mg/m2,静脉滴入.两组病例放疗方案相同.结果DF与GEM两组同期放化疗方案的有效率分别为100%和100%.1年生存率分别为94%和96%,3年生存率分别为71%和76%.血液系统毒副反应中Ⅲ～Ⅳ级血红蛋白降低及Ⅰ～Ⅱ级粒细胞减少发生率DF组较GEM组为高(P＜0.05).结论同期GEM单药放化疗组与DF放化疗组的近期疗效、1年生存率及3年生存率方面相近.GEM单药放化疗组不良反应较轻,患者耐受较好.
- [1]易俊林,高黎,黄晓东,等.鼻咽癌放射治疗的失败模式[J].2004,(3).
- [2]于世英.吉西他滨用于非小细胞肺癌治疗的研究进展[J].2001,(4).
- [3]T S, Lawrence,A, Eisbruch,D S, Shewach.Gemcitabine-mediated radiosensitization.[J].1997,24.
- [4]孙燕, 赵平主编.临床肿瘤学进展[M].2005.
- [5]D T, Chua,J S, Sham,W I, Wei,etc.The predictive value of the 1997 American Joint Committee on Cancer stage classification in determining failure patterns in nasopharyngeal carcinoma.[J].2001,92(11).