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The detection of oh8dG in Hp positive and Hp negative gastric tissue and its significance
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-6706.2006.05.002
- Key Word:
- 8-羟基-2,-脱氧鸟苷;螺杆菌感染;DNA
Abstract： 目的检测胃黏膜组织8-羟-2-脱氧鸟苷(oh8dG)表达水平,试图从幽门螺杆菌(helicobacter pylori,Hp)致胃上皮DNA氧化损伤方面探讨Hp的致癌性.方法取Hp阳性和Hp阴性胃黏膜组织各50例,采用免疫组化法检测其oh8dG表达水平.结果免疫组化显示Hp阳性和Hp阴性胃黏膜组织之间的oh8dG表达水平差异有统计学意义(P＜0.01).结论 Hp感染增加了胃黏膜组织oh8dG水平,DNA氧化损伤在Hp感染引发胃癌的过程中起重要作用.
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