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The changes of TXB2 and 6-keto-PGF1a with using ambroxol in replacement of mitral valve in beating heart
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-6706.2006.04.005
- Key Word:
- 风湿性心脏病;心脏瓣膜,人工;心肺转流术;氨溴索;花生四烯酸类;依前列醇
Abstract： 目的探讨心脏不停跳左房室瓣置换术中应用氨溴索(沐舒坦)肺保护的效果.方法风湿性心脏病患者36例随机分为实验组(应用沐舒坦)与对照组(不用沐舒坦).体外循环(CPB)90 min.于6个时点采静脉血,分别检测检测血浆血栓素(TXB2)和前列腺环素(6-keto-PGF1a).结果两组CPB期间TXB2与CPB前比较均有不同程度升高,实验组与对照组TXB2和6-keto-PGF1a在CPB中各时点差异均有统计学意义(P＜0.05).结论 TXB2可作为CPB过程中检测肺保护效果的敏感指标;心脏不停跳左房室瓣置换术中应用氨溴索(沐舒坦)可以减少TXB2的释放,具有较佳的肺保护效果.
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