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Changes and clinical significance of phosphodiestease activity in ischemic stroke patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-6706.2006.04.001
- Key Word:
- 脑梗死;磷酸二酯酶水解酶类;色谱法,高压液相
Abstract： 目的研究脑梗死患者外周血磷酸二酯酶(PDE)活性的变化及意义.方法应用高效液相色谱法(HPLC)检测298例脑梗死患者和181例对照组外周血白细胞的PDE活性,同时检测他们的血生化指标,收集临床资料,进行统计分析.结果脑梗死组外周血PDE活性为(13.78±3.12),对照组为(7.36±2.34),差异有统计学意义(P＜0.01),但外周血PDE活性与病情的严重程度无关.Logistic回归分析表明,外周血PDE活性水平与脑梗死有关(P＜0.01).结论脑梗死患者PDE活性增高,HPLC能简单易行、精密可靠地测定外周血白细胞的PDE活性,PDE在脑梗死的发病中可能起重要作用.
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