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Effect of Jian-wei decoction on the quality of ulcer healing and expression of EGFRmRNA in the rat model of gastric ulcer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1008-6706.2006.02.005
- Key Word:
- 胃溃疡;健胃汤;受体,表皮生长因子;疾病模型,动物;大鼠
Abstract： 目的探讨健胃汤对溃疡愈合质量的影响及作用机制.方法采用大鼠乙酸胃溃疡模型,观察健胃汤对该模型溃疡愈合质量的影响,并用原位分子杂交法检测表皮生长因子受体mRNA(EGFRmRNA)的表达.结果健胃汤能改善胃黏膜组织损伤并提高溃疡周围组织EGFRmRNA的表达,与模型对照组比较,差异有显著意义(P＜0.05).结论健胃汤能提高溃疡愈合质量,增强溃疡瘢痕处EGFmRNA的表达可能是其作用机制之一.
- [1]周福生,胡玲,崔琦珍,等.中医药抗消化性溃疡复发的机理研究进展[J].2001,(3).
- [2]谭永港,张永锋.健胃汤对大鼠实验性胃溃疡治疗作用及其机理研究[J].2001,(8).
- [3]张永锋,谭永港,杨敏.健胃胶囊对消化性溃疡远期疗效的研究[J].2004,(2).
- [4]杨雪松,李益农,叶嗣懋,等.大鼠胃溃疡愈合质量与抗强的松再损伤关系的实验研究[J].1996,(6).
- [5]鄢顺琴,凤良元,苏英豪,等.胃痛灵保护胃粘膜作用及对胃溃疡愈合质量的影响[J].1995,(10).
- [6]P C, Konturek,S J, Konturek,T, Brzozowski,etc.Epidermal growth factor and transforming growth factor-alpha: role in protection and healing of gastric mucosal lesions.[J].1995,7(10).