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Expression of Survivin and p53 gene and its relationship in primary hepatocellular carcinoma(HCC)
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1008-6706.2005.12.003
- Key Word:
- 癌,肝细胞;Survivin基因;基因,p53
Abstract： 目的探讨Survivin在原发性肝细胞癌(HCC)组织中的表达及与p53的关系.方法采用Western blot和RT-PCR检测43例肝癌组织、20例癌旁组织和11例正常肝组织中Survivin蛋白和mRNA的表达情况.免疫组化(SP法)检测Survivin和p53蛋白的表达情况.结果 43例HCC标本中分别有30例表达Survivin(69.8%),而除1例癌旁组织外,其他癌旁组织和正常肝组织中未见Survivin表达.Survivin表达与肝癌组织的病理分级、临床分期等无明显相关.Survivin表达与p53表达亦无明显相关.结论 Survivin在肝癌组织中高表达,Survivin的表达与p53基因的突变无明显关系.
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