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Relationship between tumornecrosis factor-α and insulin resistance in elderly patients with acute coronary syndrome
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1008-6706.2005.12.001
- Key Word:
- 急性冠状动脉综合征;肿瘤坏死因子;高胰岛素血症;胰岛素抵抗
Abstract： 目的探讨老年急性冠状动脉综合征(ACS)患者血清肿瘤坏死因子-α(TNF-α)与高胰岛素血症(HIS)及胰岛素抵抗(IR)的关系.方法采用氧化酶法、放免法和酶联免疫法分别测定50例老年急性冠脉综合征患者(ACS组)和42例正常健康人(对照组)的空腹血糖(FBG)、空腹胰岛素(FINS)及血清TNF-α值,并计算胰岛素敏感性指数(ISI).结果 ACS组FINS、TNF-α水平较对照组显著增高,而ISI较对照组显著降低.相关分析表明,老年ACS患者TNF-α与FINS呈显著正相关,而与ISI呈显著负相关.结论血清TNF-α和FINS水平升高及胰岛素敏感性减低普遍存在于ACS患者中,而且TNF-α水平升高与HIS及胰岛素抵抗程度相关,提示TNF-α与HIS及胰岛素抵抗在冠心病的发病机制中可能具有一定的内在联系.
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