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Analysis study of type 2 diabetes mellitus and those with high risk-factor in adolescents with obesity
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-6706.2005.11.003
- Key Word:
- 肥胖症;糖尿病;葡糖耐量试验;胰岛素抵抗
Abstract： 目的调查青少年肥胖者2型糖尿病(T2DM)及其高危者的发生率,探讨其高危因素.方法对68例肥胖者(12～22岁)进行口服葡萄糖耐量试验,测定空腹和2 h血糖、胰岛素水平及计算胰岛素抵抗指数(Homa-IR)及胰岛β细胞功能指数(Homa-β),并对糖代谢异常者中的8例进行干预治疗.结果 (1)68例肥胖者中发现T2DM 2例(2.9%),糖耐量异常(IGT)11例(16.2%),高胰岛素血症(HINS)28例(41.2%);(2)肥胖组其2 h血糖、胰岛素水平、2 h胰岛素与葡萄糖之比、Homa-IR及Homa-β显著高于非肥胖者(P＜0.05～P＜0.01);(3)糖代谢异常者各指标明显高于单纯性肥胖者(P＜0.05～P＜0.01);(4)8例糖代谢异常患者经干预治疗(2.3±1.2)个月,糖代谢指标显著改善.结论对青少年肥胖者应进行糖尿病筛查,对伴有糖代谢异常者应及早干预治疗,以降低青少年T2DM的发生率.
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