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Study on the pertinency between expression of TGF-β1 and its receptors and the clinical nosography in leukemic patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1008-6706.2005.08.003
- Key Word:
- 白血病;转化生长因子β
Abstract： 目的探讨急性白血病患者的转化生长因子-β1(TGF-β1)及其受体表达与白血病治疗、预后的相关性.方法收集42例初诊和经化疗完全缓解后白血病患者的外周血和骨髓,用ELISA法检测外周血、骨髓及骨髓基质细胞的可溶性TGF-β1含量;用免疫组织化学法检测外周血白血病细胞和骨髓有核细胞上的TGF-β1及其Ⅱ受体(TGFR2).结果急性白血病患者外周血、骨髓、骨髓基质细胞的TGF-β1含量明显低于对照(P<0.01),尤以血清为甚,经化疗缓解后,TGF-β1含量又升高至接近正常水平.外周血白血病细胞和骨髓有核细胞上的TGF-β1表达与对照组比较无明显差异(P>0.05).初诊患者外周血TGFR2表达明显低下,缓解后,TGFR2表达又升高至接近正常.结论急性白血病血浆、骨髓、骨髓基质TGF-β1含量与TGFR2与临床病情密切相关,可作为了解病情、观察疗效、判断预后的指标之一.
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