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Experimental study of bFGF on accelerating anastomosis healing
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1008-6706.2005.08.002
- Key Word:
- 成纤维细胞生长因子1;羟脯氨酸;吻合口
Abstract： 目的探讨小肠吻合后局部使用碱性成纤维细胞生长因子在促进肠吻合口早期愈合的作用.方法采用新西兰兔为实验动物,随机分实验组和对照组,实验组在肠吻合后吻合口喷涂碱性成纤维细胞生长因子,对照组吻合口未作特殊处理.术后第3、8天切取吻合口的肠管,分别测定肠吻合口破裂压、吻合口组织羟脯氨酸含量,并进行组织学观察.结果术后两组动物均无吻合口瘘,术后第3、8天,实验组兔肠吻合口破裂压高于对照组,但差异无显著意义;术后第3天局部肠组织羟脯氨酸多于对照组,差异有显著意义.结论碱性成纤维细胞生长因子可促进成纤维细胞增殖和胶原的合成,促进肠吻合口早期愈合,对吻合口瘘有一定预防作用.
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