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The analysis of angiogenetic factors expression in the intracranial cavernous malformations
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-6706.2005.07.002
- Key Word:
- 海绵状血管瘤;免疫组化;血管形成
Abstract： 目的通过对颅内海绵状血管瘤一大样本的免疫组化研究,了解其血管形成的特点.方法采用二步法,以血管内皮细胞生长因子(VEGF)及其受体Flt-1对临床随机选取的海绵状血管瘤50例、对照组正常脑组织血管20例分别进行免疫组化染色,根据染色强度进行对比分析.结果海绵状血管瘤中VEGF和Flt-1的表达呈明显阳性(++),弥散分布,而所有正常脑组织血管中VEGF和Flt-1则无明显表达.结论在颅内海绵状血管瘤中存在血管形成因素的过度表达现象.
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