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The level analysis of plasma endothelin-1 nitric oxide and calcitonin gene-related peptide in patients with chronic cor pulmonale
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-6706.2004.11.005
- Key Word:
- 慢性肺心病;内皮素-1;一氧化氮;降钙素基因相关肽
Abstract： 目的分析慢性肺心病(CCP)患者血浆内皮素-1(ET-1)、一氧化氮(NO)和降钙素基因相关肽(CGRP)检测的临床意义.方法应用实验研究策略,分别测定CCP急性加重期(A组,44例)、缓解期(B组,44例)和健康对照组(C组,30例)ET-1、NO和CGRP的血浆含量.结果 ET-1血浆含量在A组、B组和C组分别是(58.592±22.470)pg／ml、(47.670±17.854)pg／ml和(39.050±20.367)pg／ml,差异有显著意义(F＝8.558,P＝0.000).NO血浆含量在A组、B组和C组分别是(70.922±31.581)μmol／L、(58.110±25.211)μmol／L和(50.260±18.248)μmol／L,差异有显著意义(F＝5.873,P＝0.004).CGRP血浆含量在A组、B组和C组分别是(67.344±32.092)pg／ml、(52.205±23.912)pg／ml和(39.567±15.753)pg／ml,差异有非常显著意义(F＝10.741,P＝0.000).结论 CCP急性加重期ET-1、NO和CGRP血浆含量增高;缓解期ET-1和NO不增高,而CGRP仍高.
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