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A clinical studay of gemzar plus cisplatin or oxaliplatin in the treatment of advanced pancreatic cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1008-6706.2004.10.001
- Key Word:
- 胰腺肿瘤;吉西他滨;疗效;毒副反应
Abstract： 目的观察吉西他滨(健择)联合顺铂/草酸铂(GP/GEM-OX方案)治疗晚期不能手术或手术后复发的胰腺癌患者的疗效与不良反应.方法28例患者分别给予GP或GEM-OX方案2～13周期.按WHO标准评定疗效和不良反应.结果26例可评价疗效,无一例完全缓解(CR,0%),部分缓解(PR)7例(26.9%),稳定(SD)10例(38.5%),进展(PD)9例(34.6%).可评价临床受益反应(CBR)27例,有效率为70.4%(19/27).中位疾病进展时间为4.2个月,中位生存时间为9.3个月.结论健择联合顺铂/草酸铂是治疗晚期胰腺癌患者的安全有效方案,并能较好改善疾病相关症状,毒副反应可以耐受.
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