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Relationship between tumor necrosis fator-α and insulin resistanc in fatty liver
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1008-6706.2004.09.001
- Key Word:
- 脂肪肝;肿瘤坏死因子-α;胰岛素抵抗
Abstract： 目的探讨脂肪肝患者血清肿瘤坏死因子-α(TNF-α)水平变化及其与胰岛素抵抗之间的关系.方法用双抗体夹心ELISA法测定57例脂肪肝患者(其中肥胖组32例,非肥胖组25例)及40例正常对照组患者血清TNF-α水平,同时测定体重指数(BMI)、空腹血糖(FPG)、空腹胰岛素(FINS)、血脂,采用稳态模式(HOMA)评价胰岛素抵抗.结果①脂肪肝患者TNF-α、BMI、FPG、FINS、HOMA、胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-C)均高于对照组(P＜0.01,P＜0.05),高密度脂蛋白(HDL-C)低于对照组(P＜0.05).②肥胖、非肥胖组脂肪肝TNF-α、FPG、FINS、HOMA、TC、TG、LDL-C均高于对照组(P＜0.01,P＜0.05);肥胖组TNF-α、BMI、FINS、HOMA、TG水平明显高于非肥胖组(P＜0.01,P＜0.05);③脂肪肝患者TNF-α与HOMA、BMI、FPG、FINS、TG呈正相关,多元线性回归分析显示,TNF-α、FPG、TG是脂肪肝患者胰岛素抵抗的主要相关因素.结论脂肪肝患者无论是否肥胖都存在胰岛素抵抗、血清TNF-α水平升高,且TNF-α在胰岛素抵抗的发病环节中起着重要的作用.
- [1]刘军,陈影,姚庆姑.脂肪肝与体重、血脂、血糖、胰岛素抵抗的关系[J].2003,(8).
- [2]J H, Lee,P L, Rhee,J K, Lee,etc.Role of hyperinsulinemia and glucose intolerance in the pathogenesis of nonalcoholic fatty liver in patients with normal body weight.[J].1998,13.
- [3]W J, Lee,R L, Chang,Y T, Chen.Plasma tumor necrosis factor alpha levels and insulin sensitivity in hypertensive subjects.[J].2000,22(6).