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Dynamic changes and the significance of inflammatory cytokines in acute myocardial infarction
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1008-6706.2004.06.004
- Key Word:
- 急性心肌梗死;C-反应蛋白;肿瘤坏死因子α;纤维蛋白原 白细胞介素6
Abstract： 目的探讨炎症标记物与急性心肌梗死(AMI)的关系和临床意义.方法选择AMI病人63例,正常对照组36例作对比研究.对照组于入院早晨采集静脉血,AMI组分别于抢救前、发病后12 h、24 h、48 h、3 d、4 d、7 d、14 d、1个月和2个月时早晨空腹采血.采用免疫比浊法测定C-反应蛋白(CRP)浓度,酶联免疫吸附双抗体夹心法检测肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)浓度,全自动血凝仪自动检测枸橼酸钠抗凝的血浆中纤维蛋白原(Fg)浓度.结果AMI组与对照组比较,血清中CRP、TNF-α、Fg、IL-6浓度均显著增高(P＜0.05);在2周内均有明显动态变化.结论炎症参与了心肌梗死的发病全过程,血清中炎性细胞因子水平的高低和病情严重程度及病程有关,炎性细胞因子的动态演变可作为动脉粥样硬化斑块的稳定性指标,以判断病情和预后.
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