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Correlation of angiotensin-converting enzyme(ACE) gene insertion/deletion polymorphism with prethrombotic state and essential hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-6706.2004.05.003
- Key Word:
- 高血压;血管紧张素转换酶;基因多态性;血栓前状态
Abstract： 目的探讨血管紧张素转换酶(ACE)基因I/D多态性与原发性高血压(EH)及高血压血栓前状态(PTS)的关系.方法 PCR检测61例原发性高血压病人和正常对照组28例的ACE基因I/D多态性;发色底物法测t-PA、PAI-1活性,酶联免疫吸附双抗夹心法(ELISA)测vWF含量.结果高血压组DD基因型频率显著高于对照组(P＜0.05),但D等位基因频率分布在高血压组和正常组之间差异无显著意义(P＞0.05).高血压组t-PA活性降低,PAI-1活性、vWF含量升高(P均＜0.001).高血压组DD型t-P活性明显低于ID、II型(P＜0.001),而ID、II型之间差异无显著意义(P＞0.05),DD型PAI-1活性明显高于ID、II型(P＜0.001),而ID、II型之间差异无显著意义(P＞0.05),vWF在DD、ID、II型三者之间差异无显著意义(P＞0.05).结论 DD型是原发性高血压发病的危险因素.原发性高血压存在血栓前状态.t-PA、PAI-1的变化与血管紧张素转换酶基因I/D多态性有关,DD基因型可引起血栓前状态.
- [1]Rigat B,Hubert C,Alhenc-Gelas F,etc.An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.[J].1990.
- [2]F S, Malik,C J, Lavie,M R, Mehra,etc.Renin-angiotensin system: genes to bedside.[J].1997,134(3).