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A comparision between NO and ET-1 in plasma and tissue by differrent treatment with lupus nephritis(LN)
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-6706.2004.04.003
- Key Word:
- 狼疮肾炎;内皮素-1;一氧化氮
Abstract： 目的研究狼疮肾炎(LN)病人组织及血浆内皮素-1(ET-1)和一氧化氮(NO)检测的临床意义.方法用放免法、ABC染色法及比色法分别对40例LN病人分组测定ET-1和NO含量变化.结果 LN病人肾组织ET-1和NO的表达及血浆ET-1和NO含量均高于对照组,治疗后低于治疗前(P＜0.05～0.01),并随时间呈下降趋势;肾受损程度越重,血浆ET-1和NO含量越高;肾组织ET-1表达与血浆含量间呈正相关(r＝0.61～0.63,P均＜0.05).结论 LN病人测定组织及血浆NO、ET-1的含量可能对临床诊断和病情判断有帮助.
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