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Effect of irbesartan combined with benazapril on reversing left ventricular hypertrophy in patients with essential hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1008-6706.2004.01.002
- Key Word:
- 高血压;左心室肥厚;伊贝沙坦;苯那普利
Abstract： 目的探讨伊贝沙坦、苯那普利联合用药对原发性高血压(EH)病人左室肥厚(LVH)的逆转作用.方法 EH伴有LVH病人112例随机分为A组(伊贝沙坦150 mg/d,38例)、B组(苯那普利10 mg/d,37例)和C组(伊贝沙坦150 mg/d,加苯那普利10 mg/d,37例).治疗3周时若血压≥160/95 mmHg,则伊贝沙坦和苯那普利剂量分别增加1倍.总疗程共6个月,治疗前后24 h动态血压监测和彩色超声多普勒检测左室相关指标,计算左室重量指数(LVMI).结果①三组均能显著降低LVMI(P＜0.01),其中A组和B组LVMI的降低差异无显著意义(P＞0.05),C组LVMI降低较A组、B组更为显著,差异有显著意义(P＜0.01).②三组治疗前24 h平均收缩压、平均舒张压差异无显著意义(P＞0.05),治疗后24 h平均收缩压、平均舒张压均较治疗前显著降低(P＜0.01),但治疗后三组间比较均无明显差异(P＞0.05).结论伊贝沙坦、苯那普利均能逆转EH病人LVH,联合用药疗效更为显著,这种协同作用与降压效应无关.
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