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Clinical significance of plasma endothelial function on senile chronic cor pulmonale
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-6706.2003.11.003
- Key Word:
- 慢性肺心病;血浆内皮功能;血浆内皮素-1;血管性假血友因子
Abstract： 目的观察老年慢性肺心病血浆内皮功能即血浆内皮素-1(ET-1)和血管性假血友因子(vWF)测定的临床意义.方法随机抽取老年慢性肺心病病人高危组和低危组各30例,入院第1 d晨空腹采肘静脉血,分离血浆后,用放射免疫法和双抗夹心酶联免疫吸附法,进行ET-1和vWF的含量测定,并与体检健康老年组30例做对照,进行统计学处理.结果血浆ET-1和vWF含量测定值,低危组较对照组增高,P＜0.05;高危组较低危组增高,P＜0.05;老年慢性肺心病组(高危组+低危组)较对照组显著增高,P＜0.01;高危组较对照组显著增高,P＜0.01.结论老年慢性肺心病病情越重其ET-1和vWF值增高越明显,两者呈正相关,ET-1和vWF值越高,预后越差.血浆内皮功能测定可作为判断老年肺心病病人预后的指标之一.
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