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Study of prethrombotic state(PTS) in patients with obstructive sleep apnea-hypopnea syndrome
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1008-6706.2003.10.011
- Key Word:
- 血栓前状态;阻塞性睡眠呼吸暂停低通气综合征;睡眠呼吸暂停低通气指数
Abstract： 目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)病人是否存在血栓前状态.方法选择年龄、性别、体重指数(BMI)无明显差异的OSAHS病人52例和健康者48例,用多导睡眠呼吸监测仪进行监测,以Clauss法测定Fg,以发色底物法测组织纤溶酶原激活物活性(tPA∶A)、纤溶酶原激活物抑制物-1活性(PAI-1∶A),抗凝血酶-Ⅲ活性(AT-ⅢA),以酶联免疫法测von Willebrand因子(vWF)、组织纤溶酶原激活物抗原(tPA∶Ag)、纤溶酶原含量(PLg∶Ag)和纤溶酶原激活物抑制物-1含量(PAI-1∶Ag).以免疫火箭电泳法测抗凝血酶-Ⅲ抗原(AT-ⅢAg).结果 OSAHS组与对照组比较vWF、Fg、PAI-1∶A、PAI-1∶Ag明显升高(P分别＜0.001、0.05、0.01、0.05),AT-ⅢAg、AT-ⅢA、PLg∶Ag、tPA∶Ag明显降低(P分别＜0.01、0.05、0.05、0.05).结论 OSAHS病人存在血栓前状态.
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