You Position: Home > Paper
Clinical study on the relationship between left ventricular diastolic function in patients with essential hypertension and the serum concentration of leptin
( views:176, downloads:8 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-6706.2003.07.006
- Key Word:
- 高血压;左室舒张功能;瘦素;多普勒组织成像
Abstract： 目的探讨原发性高血压(EH)病人左室舒张功能与血清瘦素(Leptin)浓度的关系.方法采用放免法测定30例正常人和54例EH病人的血清瘦素浓度.用多普勒组织成像(DTI)技术检测正常人及EH病人二尖瓣环舒张早期运动速度(Ea)、舒张晚期运动速度(Aa)及Ea/Aa,比较其测值与血清瘦素浓度的相关性.结果 EH病人组二尖瓣环DTI参数明显低于正常对照组(P＜0.01);EH病人组血清瘦素浓度与Ea、Ea/Aa呈负相关(r＝-0.41,P＜0.01;r＝-0.43,P＜0.01).结论检测血清瘦素浓度有利于EH病人左室舒张功能受损程度的判断.
- [1]陈刚,罗敏.Leptin受体与肥胖[J].2000,(6).
- [2]晋学庆,吴可贵.瘦素对自发性高血压大鼠血管平滑肌细胞增殖的影响[J].2002,(2).
- [3]朱文晖,李瑞珍,张梦玺,等.多普勒组织成像技术对高血压患者左室舒张功能的评价[J].2003,(2).
- [4]鲁伟,刘培庆,王庭槐,等.MAPK信号途径在一氧化氮抑制大鼠心肌肥大中的作用[J].2001,(1).
- [5]PaoloM Suter,Rudolf Locher,Erik Häsler,etc.Is there a role for the ob gene product leptin in essential hypertension?[J].1998,11(11).
- [6]Shimabukuro M,Koyama K,Lee Y,etc.Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.[J].1997.
- [7]Ahn NG,Shapiro PS.Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1).[J].1998,273(3).