You Position: Home > Paper
The effect of Naojian granule on AD mouse's mitochondrial structure and ion pump ATP enzyme
( views:122, downloads:4 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-6706.2003.05.004
- Key Word:
- 脑健冲剂;β-淀粉样蛋白;AD线粒体结构;离子泵ATP酶
Abstract： 目的观察脑健冲剂对AD大鼠线粒体结构及离子泵ATP酶的影响.方法采用D-半乳糖致衰老基础上β-淀粉样蛋白颅内注射所致AD大鼠模型.将Wista大鼠随机分为6组:空白组、假损伤组、模型组、对照组、治疗组、保护组,通过电镜观察及比色法,观察脑健冲剂的作用.结果脑健冲剂能使AD大鼠的Ca+-ATP酶、Ca2+Mg2+-ATP酶、Na+K+-ATP酶活力水平明显提高.用药组的线粒体体密度、面数密度和平均截面积与模型组相比差异有非常显著意义(P＜0.01).结论脑健冲剂能改善AD大鼠的线粒体损伤程度,提高AD大鼠的线粒体离子泵ATP酶的活力.
- This article has no references!