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Study on ras and p53 gene mutation of urothelial tumors
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-6706.2003.03.004
- Key Word:
- 尿路上皮肿瘤;癌;基因
Abstract： 目的研究 K-ras和p53基因突变与尿路上皮肿瘤的预后关系.方法应用聚合酶链式反应加单链多态性分析(PCR-SSCP)检测52例尿路上皮肿瘤K-ras和p53基因突变.[ HT5"H 结果 K-ras基因突变率为9.6%(5/52),p53基因突变率为42.3%(22 /52).结论尿路上皮肿瘤发生和发展牵涉多基因多步骤途径,p53 基因突变对尿路上皮肿瘤预后有预测意义.
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