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Clinical study of mycophenolate mofetil plus prednisone in patients with lupus nephritis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1008-6706.2002.12.001
- Key Word:
- 霉酚酸酯;环磷酰胺;狼疮性肾炎;疗效
Abstract： 目的观察霉酚酸酯(骁悉)联合强的松治疗LN的临床疗效和不良反应.方法 43例狼疮性肾炎随机分为骁悉联合强的松和环磷酰胺联合强的松治疗组,采用ELISA、间接免疫荧光法、生化法等检测两组病人血清细胞因子IL-6、IL-8、TNF-α水平,自身抗体,补体C3、C4,肝功、肾功和尿蛋白等指标.结果与环磷酰胺联合强的松治疗相比,病人经骁悉联合强的松治疗后血清IL-6、IL-8、TNF-α水平,抗核抗体、A-dsDNA抗体水平,血尿素氮、肌酐以及尿蛋白水平均明显降低;血C3、C4增高更为明显,且病人无明显的骨髓抑制和肝功能损害.结论骁悉联合强的松治疗狼疮性肾炎疗效好、安全性高,值得推广应用.
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