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Qualitative and quantitive study of bax and bcl-2 protein expression in esophageal carcinona
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-6706.2002.03.002
- Key Word:
- 食管肿瘤 bax bcl-2 免疫组化 流式细胞术
Abstract： 目的探讨bax和bcl-2蛋白表达在食管癌发生和发展中的作用.方法应用免疫组化、流式细胞术和细胞免疫荧光技术对70例食管鳞癌组织bax和bcl-2蛋白进行定性和定量检测.结果免疫组化研究示bax蛋白阳性表达32例,bcl-2蛋白阳性表达43例,bax和bcl-2蛋白表达与肿瘤病理分级和淋巴结转移密切相关(P＜0.05),但与临床分期之间差异无显著意义(P＞0.05);流式细胞定量研究示bax蛋白阳性表达39例,bcl-2蛋白阳性表达65例,bax和bcl-2蛋白表达率和表达量与肿瘤病理分级、分期和淋巴结转移无明显相关(P＞0.05).结论 bax和bcl-2蛋白的异常表达在食管癌发生和发展中起重要作用.
- [1]Odd Mørkve,Ole Didrik Laerum.Flow cytometric measurement of p53 protein expression and DNA content in paraffin-embedded tissue from bronchial carcinomas[J].1991,12(5).
- [2]Mario Sarbia,Fernando Bittinger,Florian Grabellus,etc.Expression of Bax, a pro-apoptotic member of the Bcl-2 family, in esophageal squamous cell carcinoma[J].1997,73(4).
- [3]Mario Sarbia,Fernando Bittinger,Rainer Porschen,etc.Bcl-2 Expression and Prognosis in Squamous-Cell Carcinomas of the Esophagus[J].1996,69(4).