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The morphometry study on the cytotoxic effect of phenethylbiguanide on islet A cells
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-6706.2002.03.001
- Key Word:
- 降糖灵;胰岛A细胞;毒性作用;形态计量学;大鼠
Abstract： 目的探讨降糖灵对胰岛A细胞毒性作用的选择性.方法应用免疫组织化学、透射电镜及体视学方法,研究大鼠肌注降糖灵50 mg/kg后胰岛细胞的形态变化.结果肌注降糖灵2 d后胰岛A细胞有损伤改变(P＜0.05),4 d后恢复.胰岛内B细胞、D细胞、PP细胞及外分泌部无明显变化.结论降糖灵可选择性破坏大鼠胰岛A细胞,病变稳定、选择性高,是进一步研究A细胞功能的理想的实验工具.
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