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Expression and significance of EGFR、c-myc、PCNA in colorectal carcinomas
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1008-6706.2002.02.005
- Key Word:
- 大肠癌 EGFR c-myc PCNA 免疫组织化学
Abstract： 目的研究EGFR、c-myc与PCNA在大肠癌中表达的意义及其相关性.方法应用免疫组织化学SABC法检测82例大肠癌组织及20例"正常"粘膜中EGFR、c-myc与PCNA的表达.结果 "正常"粘膜中无EGFR高表达,癌组织中EGFR、c-myc高表达率分别为63.4%和46.3%,癌组织中PCNA-LI为78.6%±17.1%,显著高于"正常"粘膜中24.6%±10.7%.癌组织中EGFR、C-myc高表达和PCNA-LI与大肠癌的分化程度、淋巴结转移及Dukes分期相关.癌组织中EGFR、c-myc高表达和PCNA-LI三者间均存在正相关关系.结论检测大肠癌组织中EGFR、c-myc与PCNA表达对判断大肠癌的生物学行为有一定的价值.大肠癌组织中EGFR、c-myc表达增高与其高增殖活性有关.
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