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Different chemotherapeutic scheme plus radiation for inoperable stage Ⅲ non-small cell lung cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-6706.2001.04.005
- Key Word:
- 非小细胞肺癌;化疗;放疗;联合治疗
Abstract： 目的评价不同化疗方案加放射治疗不能手术的Ⅲ期非小细胞肺癌(non small cell lung cancer,NSCLC)疗效.方法57例不能手术的Ⅲ期NSCLC病人分为两组.29例病人接受紫杉醇(PTX)210 mg,第1天;顺铂20 mg,第1～5天联合化疗(PP方案)2个疗程,同时给予放疗(治疗组).28例病人采用足叶乙甙100 mg,第1～5天;顺铂20 mg,第1～5天化疗2个疗程(EP方案),同时予以放疗(对照组).两组放疗方式和剂量相同,常规分割放射,每次2 Gy,每周5次,原发灶和淋巴结受累部位的总剂量为60～70 Gy,淋巴引流区40 Gy.结果治疗组总有效率为82.8%,完全缓解率(CR)10.4%;对照组总有效率53.6%,CR 17.9%.两组总有效率统计学处理差异有显著意义(P＜0.05).化疗的毒副作用主要是胃肠道反应和骨髓抑制.结论PP方案加放疗治疗不能手术的Ⅲ期NSCLC,毒性可耐受,疗效明显优于EP方案加放疗.
- [1]史鹤玲,唐俊舫,宋剑虹,等.紫杉醇治疗非小细胞肺癌临床观察[J].1997,(3).
- [2]M G, Trovò,E, Minatel,A, Veronesi,etc.Combined radiotherapy and chemotherapy versus radiotherapy alone in locally advanced epidermoid bronchogenic carcinoma. A randomized study.[J].1990,65(3).
- [3]王毓洲,郭胤仕,邢祖林.足叶乙甙、顺氯氨铂联合胸部放疗治疗局限性晚期肺鳞癌疗效观察[J].1996,(10).
- [4]J C, Breneman,S E, Mitchell,D K, Hawley,etc.Concurrent radiotherapy and chemotherapy for locally advanced non-small-cell cancer of the lung. Report of a clinical trial and review of the literature.[J].1991,14.
- [5]徐光川,刘国贞,朱兰才,等.诱导化疗加放疗与单纯放疗不能手术的Ⅲ期非小细胞肺癌[J].1997,(4).
- [6]M B, Hazuka,A T, Turrisi.The evolving role of radiation therapy in the treatment of locally advanced lung cancer.[J].1993,20(2).