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Research progress in association between angiopoietin-like protein 2 and inflammation-related diseases

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF PATHOPHYSIOLOGY

Issue:: 11

DOI:: 10.3969/j.issn.1000-4718.2012.11.014

Key Word:: 血管生成素样蛋白2;炎症相关性疾病

Abstract： @@ 血管生成素样蛋白2属于血管生成素样蛋白家族(angiopoietin-like proteins,ANGPTLs),该类蛋白是近年来发现的新一类血管发生相关蛋白因子,属于分泌性糖蛋白.目前已知的ANGPTLs共有7个成员, 分别为ANGPTL1～7[1].ANGPTLs与血管生成素具有一定的同源性以及相似的结构特征:氨基端卷曲螺旋结构域(coiled-coil domain,CCD)和羧基端纤维蛋白原样结构域(fibrinogen-like domain,FLD)[2],但ANGPTLs均不能与血管生成素受体/酪氨酸激酶Tie1或Tie2结合,在功能上也表现出多样性.已经证实ANGPTL1及ANGPTL4会对血管发生起抑制作用,ANGPTL3和ANGPTL6具有促血管发生作用,同时,ANGPTL3及ANGPTL4还具有调节糖、脂及能量代谢的作用,ANGPTL6具有抗肥胖及胰岛素抵抗的作用[1].目前,对于ANGPTL2和ANGPTL5的研究仍相对有限.

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