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Effect of short-chain acyl-CoA dehydrogenase on cardiac hypertrophy induced by hypertension or exercise training
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PATHOPHYSIOLOGY
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1000-4718.2012.11.001
- Key Word:
- 心肌肥大;高血压;运动;短链酰基辅酶A脱氢酶;脂肪酸氧化
Abstract： 目的:研究短链酰基辅酶A脱氢酶(short-chain acyl-CoA dehydrogenase,SCAD)在大鼠生理性和病理性心肌肥大中的变化,探讨其与心肌肥大之间的关系.方法:以自发性高血压大鼠作为病理性心肌肥大模型,游泳运动训练性大鼠作为生理性心肌肥大模型.检测大鼠的血压、左室重量指数、血清和心肌游离脂肪酸含量、SCAD mRNA、蛋白表达及其酶活性的变化,采用超声心动图观察心脏的结构及功能.结果:与对照组比较,运动组大鼠出现了明显的离心性肥大,心肌收缩功能增强;而高血压组大鼠呈现出明显的向心性肥大,心肌收缩功能减退.与对照组比较,运动组和高血压组大鼠的左室重量指数均明显增高,但两组间比较无显著差异,二者发生了相同程度的心肌肥大.与对照组比较,运动组大鼠左心室SCAD mRNA和蛋白表达均明显上调,酶活性增高,血清和心肌游离脂肪酸含量明显减少;而自发性高血压大鼠左心室SCAD mRNA和蛋白表达均明显下调,酶活性下降,血清和心肌游离脂肪酸含量明显增多.结论:SCAD在生理性和病理性心肌肥大中呈现出不一致的变化趋势,可能作为区别2种不同心肌肥大的分子标志物以及病理性心肌肥大的潜在治疗靶点.
- [1]张超英,李晓惠.容量负荷与心室结构重建的研究进展[J].2011,(2).
- [2]冯兵,徐静,刘伟,等.肥大心肌细胞缺氧复氧损伤特点及干预能量代谢的作用[J].2007,(3).
- [3]刘晓红,吕元红.线粒体脂肪酸氧化缺陷与能量代谢研究[J].2006,(8).
- [4]J E, Bishop,L A, Kiernan,H E, Montgomery,etc.Raised blood pressure, not renin-angiotensin systems, causes cardiac fibrosis in TGR m(Ren2)27 rats.[J].2000,47(1).
- [5]任绮.耐力训练对逆转大鼠实验性心肌肥厚的干预作用[J].2011,(3).
- [6]Finck BN,Kelly DP.Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease.[J].2007,115(19).
- [7]Horizoe,Y.,Ueya,N.,Yuasa,T.,etc.Left ventricular dysfunction assessed by cardiac time interval analysis among different geometric patterns in untreated hypertension[J].2012,76(6).
- [8]Guenter, Haemmerle,Tarek, Moustafa,Gerald, Woelkart,etc.ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.[J].2011,17(9).
- [9]Bernardo BC,Weeks KL,Pretorius L,etc.Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies.[J].2010,128(1).
- [10]马继政,孙飙,吕远远.运动性心肌肥大大鼠心肌蛋白差异表达研究[J].2010,(2).
- [11]Goetzman ES.The regulation of acyl-CoA dehydrogenases in adipose tissue by rosiglitazone.[J].2009,17(1).
- [12]Chen JW,Liu PQ,Huang M,etc.Proteomic analysis of hypertrophied myocardial protein patterns in renovascularly hypertensive and spontaneously hypertensive rats[J].2006,5(11).
- [13]Pena,L.,Burton,B.,Charrow,J.,etc.Follow-up of patients with short-chain acyl-CoA dehydrogenase and isobutyryl-CoA dehydrogenase deficiencies identified through newborn screening: One centers experience[J].2012,14(3).
- [14]Foryst-Ludwig, Anna,Kreissl, Michael C.,Sprang, Christiane,etc.Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability.[J].2011,70(1).