You Position: Home > Paper

Typical Cell Signaling Response to Ionizing Radiation:DNA Damage and Extranuclear Damage

( views:140, downloads:0 )
Author:
No author available
Journal Title:
Chinese Journal of Cancer Research
Issue:
2
DOI:
10.1007/sl1670-012-0083-1
Key Word:
Radiation;Bystander effect;DNA damage;Extranuclear damage

Abstract: To treat many types of cancer,ionizing radiation (IR) is primarily used as external-beam radiotherapy,brachytherapy,and targeted radionuclide therapy.Exposure of tumor cells to IR can induce DNA damage as well as generation of reactiveoxygen species (ROS) and reactive nitrogen species (RNS) which can cause non-DNA lesions or extracellular damage like lipid perioxidation.The initial radiation-induced cell responses to DNA damage and ROS like the proteolytic processing,as well as synthesis and releasing ligands (such as growth factors,cytokines,and hormone) can cause the delayed secondary responses in irradiated and unirradiated bystander cells through paracrine and autocrine pathways.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn