Abstract: Access to domestic and foreign literatures, the status and lack of metabolic study on Chinese materia medica (CMM) have been overviewed; The basis for establishing the zebrafish metabolic model of CMM has been analyzed; The thoughts and methods for the establishment of the model have been put forward. The metabolic model of zebrafish could be expected to provide a simple, model, biological, systematic, and efficient new method for CMM metabolic study. It is of great significance to enhance the research level of physiological disposition of CMM and to accelerate the modernization process of CMM.