Application of PK-PD methods based on metabonomics and "FANG-ZHENG Correspondence" to investigating compatibility of Chinese material medica
- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0253-2670.2009.02.001
- Key Word:
- 代谢组学;方证对应;药效学;药动学;复方配伍规律;metabonomics;FANG-ZHENG correspondence;pharmacokinetics (PK);pharmacody- namics (PD);compatibility of formulae
Abstract： The systematic approaches of metabonomics are similar to the essential attribution in con- cept of the wholism for traditional Chinese medicine (TCM) theories. The metabonomics had been pro- gressively utilized to study the TCM theories, such as "ZHENG" (synelromes), or the systematic mecha- nism of Chinese materia medica (CMM) and its formulae by animal models, and toxicology in recent years. These studies almost focused on the responeses of endogenous metabonome to biological stimuli or genetic manipulation (pharmacodynamics and toxicology) by TCM theory of "ZHENG", while less involved the precess of formulae itself and its dynamic changes (pharmacokinetics) by TCM theory of "FANG". The "treatment by differentiating syndrome" and "Correspondence of FANG-ZHANG" is the quintessence of TCM theories. Consequently, in this idea, the application of PK-PD methods based on metabonomics and "FANG-ZHENG correspondence" to investigating the compatibility of the formulae in TCM theory is dis- cussed in this paper.
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