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A new hypothesis on formula metabonomics
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- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0253-2670.2007.06.001
- Key Word:
- 方剂代谢物组学;多靶点;大承气汤;急性胰腺炎
Abstract： 药效物质基础是方剂研究的核心之一.要弄清方剂多成分、多靶点作用,首先要弄清是什么成分、什么途径、什么靶点.以大承气汤为代表的攻下方剂临床疗效确切,但药效物质基础不清,体内作用靶点不明.从方剂体内成分及疗效出发,采用高效液相色谱-质谱-质谱联用法研究大承气汤在急性胰腺炎模型的方剂药效成分及药动学;再将方剂吸收进入体内的成分作为药物进行方剂来源成分的药效学研究,联用代谢物组学方法从代谢物变化出发探索方剂作用多靶点的生化-药效物质基础,阐明方剂作用途径和药效学,以探索大承气汤治疗具有"阳明腑实证"的急性胰腺炎的药效物质基础和作用的确切靶点;从中医学整体观出发,创新性运用代谢物组学的整体分析方法研究"阳明腑实证"的证本质,从而建立方剂代谢物组学新假说.
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