Caffeoylquinic acid derivatives from Bidens parviflora and their antihistamine release activites
- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0253-2670.2006.07.002
- Key Word:
- 小花鬼针草;咖啡酰奎宁酸;组胺抑制活性;Bidens parviflora Willd.;caffeoyl quinic acid;anti-histamine release
Abstract： Objective Based on the activities of antihistamine release to study the compounds from Bidens parvi-flora and find biological active compounds. Methods The chemical constituents from B.parviflora were isolated by silica gel and Sphadex LH-20 column chromatographies and purified by preparative HPLC. The chemical structures had been identified by physiochemical properties and spectroscopic methods. Results Six caffeoylquinic acid derivatives were identified as 3, 5-di-O-caffeoylquinic acid ( Ⅰ ),3, 4-di-O-caffeoylquinic acid ( Ⅱ ), 4, 5-di-O-caffeoylquinic acid ( Ⅲ ), 4-O-caffeoylquinic acid ( Ⅳ ), 5-O-caffeoylquinic acid ( Ⅴ ), 4-[3-(3, 4-dihydroxy-phenyl)-acryloyloxy]-2, 3-dihydroxy-2-methyl-butyric acid ( Ⅵ ). Conclusion Compounds Ⅰ - Ⅵ are first obtained from B. parviflora and Ⅵ is new one. Some of the compounds exhibit the activities in antiallergic assays. Moreover, the structure-activity relationships of these compounds have been also discussed in this paper.
- [1]Schinella G,Gongora L,Manez S,etc.Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid.[J].2003,69(5).
- [2]Kazunori Ogawa,Yutaka Sashida.Caffeoyl derivatives of a sugar lactone and its hydroxy acid from the leaves of Bidens pilosa[J].1992,31(10).
- [3]Schinella G,Manez S,Rios JL,etc.Effects of caffeoyl conjugates of isoprenyl-hydroquinone glucoside and quinic acid on leukocyte function.[J].2002,71(25).
- [4]Knowles R G,Moncada S.Nitric oxide synthases in mammals[J].1994.
- [5]Susumu Kitanaka,Naili Wang,Xinsheng Yao,etc.Antiallergic Agents from Natural Sources.3. Structures and Inhibitory Effects on Nitric Oxide Production and Histamine Release of Five Novel Polyacetylene Glucosides from Bidens parviflora Willd.[J].2001,49(8).
- [6]De-Tommasi N,Piacente S,Pizza C.Flavonol and chalcone ester glycosides from Bidens andicola.[J].1998,61(8).
- [7]Wang NL,Kitanaka S,Yao XS,etc.Bioactive sucrose esters from Bidens parviflora[J].2003,62(5).
- [8]ISHII Rie,SAITO Koichi,HORIE Masakazu,etc.Inhibitory Effects of Hydrolyzable Tannins form Melastoma dodecandrum LOUR. on Nitric Oxide Production by a Murine Macrophage-Like Cell Line, RAW264.7, Activated with Lipopolysaccharide and Interferon-γ[J].1999,22(6).