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Synthesis of novel acylamide derivatives of glycyrrhetinic acid containing isoxazole
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- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0253-2670.2006.03.005
- Key Word:
- 甘草次酸;酰胺衍生物;异噁唑;抗炎活性
Abstract： 目的合成甘草次酸酰胺的异噁唑衍生物,寻找活性好的抗炎药物.方法以甘草次酸为原料,与3-取代苯基-5-异噁唑甲胺进行偶联,合成了6个新型甘草次酸酰胺类衍生物,采用IR、1H-NMR、13C-NMR、MS等方法确定其化学结构.以二甲苯引起的小鼠耳肿模型和醋酸引起的小鼠腹膜炎模型评价了抗炎活性.结果IR、1H-NMR、13C-NMR、MS等数据表明这些化学结构正确.其中,化合物Ⅳ具有明显的抗炎活性.结论合成的系列新化合物结构正确,发现了一个抗炎活性较强的化合物.
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