You Position: Home > Paper
Sesquiterpene components of Laurencia tristicha
( views:170, downloads:0 )
- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0253-2670.2006.03.004
- Key Word:
- 三列凹顶藻;倍半萜;细胞毒活性
Abstract： 目的从三列凹顶藻Laurenciatristicha中寻找具有多样性结构的倍半萜化学成分,供药理活性筛选.方法采用凝胶柱色谱、硅胶柱色谱、重结晶和高效液相色谱等方法进行分离;借助包括一维和二维NMR等波谱方法和X-单晶衍射鉴定化合物的结构;用MTT法对得到的化合物进行细胞毒活性评价.结果分离得到5个倍半萜类化合物,分别鉴定为海兔阿普里素(aplysin,Ⅰ)、海兔阿普里醇(aplysinol,Ⅱ)、去溴海兔阿普里醇(debro-moaplysinol,Ⅲ)、凹顶藻联苯(laurebiphenyl,Ⅳ)、约翰斯顿醇(johnstonol,Ⅴ);在人肿瘤细胞株HCT-8、Bel-7402、BGc-823、A549和HeLa模型上,化合物Ⅳ对所有细胞株均显示毒性,化合物Ⅲ对HeLa细胞显示中等强度的细胞毒活性,其他化合物对所有细胞株均无明显毒性,IC50均大于10.0μg/mL.结论化合物Ⅰ～Ⅴ均为首次从三列凹顶藻中得到,化合物Ⅲ对HeLa细胞具有中等强度的选择性细胞毒活性,化合物Ⅳ对所有细胞株均显示毒性.
- [1]Minoru Suzuki,Etsuro Kurosawa.Halogenated and Non-halogenated Aromatic Sesquiterpenes from the Red Algae Laurencia okamurai Yamada[J].1979,52(11).
- [2]J, Carmichael,W G, DeGraff,A F, Gazdar,etc.Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.[J].1987,47(4).
- [3]J.Yves Laronze,Rachida El Boukili,Dominique Patigny,etc.The rearrangement of some cyclopentanone-aryloximes: synthesis of (±)-aplysin, (±)-filiformin and of their debromo analogues.[J].1991,47(48).
- [4]Suzuki M,Daitoh M,Vairappan CS,etc.Novel halogenated metabolites from the Malaysian Laurencia pannosa.[J].2001,64(5).
- [5]James J. Sims,William Fenical,Richard M. Wing,etc.Marine natural products III. Johnstonol, an unusual halogenated epoxide from the red alga Laurencia johnstonii[J].1972,13(3).
- [6]Yoshikazu Shizuri,Kiyoyuki Yamada.Laurebiphenyl, a dimeric sesquiterpene of the cyclolaurane-type from the red alga Laurencia nidifica[J].1985,24(6).
- [7]Masuda M,Suzuki M,Vairappan CS,etc.Halogenated metabolites with antibacterial activity from the OkinawanLaurencia species[J].2001,58(3).
- [8]De Clercq E.,Iliopoulou D.,Vagias C.,etc.Halogenated sesquiterpenes from the red alga Laurencia obtusa[J].2002,58(33).
- [9]Howes PD.,Harrowven DC.,Lucas MC..The synthesis of a natural product family: from debromoisolaurinterol to the aplysins[J].2001,57(4).
- [10].N. Ayyad,J. Jakupovic,M. Abdel-Mogib.A sesquiterpene ether from Laurencia obtusa[J].1994,36(4).